Avana, also known as avanafil, is a medication primarily used to treat erectile dysfunction (ED). While it is generally well-tolerated, there are certain medical conditions that may interact negatively with Avana or require special consideration. It's essential to inform your healthcare provider of your complete medical history and any existing conditions before starting Avana. Avana can lower blood pressure. If you have a history of heart disease, heart attack, stroke, arrhythmias, or unstable angina, the use of Avana may be contraindicated or require careful monitoring. Combining Avana with nitrates or alpha-blockers used to treat heart conditions can lead to a dangerous drop in blood pressure. Avana is metabolized in the liver and excreted through the kidneys. If you have liver or kidney impairment, your healthcare provider may need to adjust the dosage of Avana or consider alternative treatments. Individuals with a history of priapism (prolonged and painful erections) should use Avana with caution, as it may increase the risk of recurrent priapism. Avana may affect vision, and individuals with retinal disorders like retinitis pigmentosa should use this medication cautiously and under the supervision of an ophthalmologist. Avana can increase the risk of bleeding. If you have a bleeding disorder or are taking blood-thinning medications, consult your healthcare provider before using Avana. Excessive alcohol or drug use can contribute to ED and may interact negatively with Avana. It's essential to discuss substance use with your healthcare provider. Inform your healthcare provider of any allergies or sensitivities you have to medications or their ingredients.