Pentobarbital is a drug from the barbiturate family synthesized in 1928 that can be found in acid or salt form. The best-known trade name for this drug is Nembutal, first used in 1930, and marketed in the form of sodium salt.
Formula : C 11 H 18 N 2 O 3
Molar mass : 226.276 g/mol
CAS number: 76-74-4
What Is Nembutal & How Is It Used?
Nembutal (pentobarbital sodium) is a barbiturate that acts as a depressant, or sedative used short-term to treat insomnia. Nembutal is also used for committing suicide. Nembutal (pentobarbital sodium) is a barbiturate that acts as a depressant or sedative, used short-term to treat insomnia. Nembutal is also used as an emergency treatment for seizures, and to cause patients to fall asleep for surgery. Nembutal is available in generic form.
Barbiturates are nonselective central nervous system depressants that are primarily used as sedative hypnotics and also anticonvulsants in sub-hypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See "Drug Abuse and Dependence" section).
The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions.
Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance that has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.
NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 100 mg, in a vehicle of propylene glycol, 50%, alcohol, 20%, and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide.
NEMBUTAL (pentobarbital) Sodium is a short-acting barbiturate, chemically designated as sodium 5-ethyl-5-(1-methyl butyl) barbiturate. The structural formula for pentobarbital sodium is:
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Sodium salt occurs as a white, slightly bitter powder that is freely soluble in water and alcohol but practically insoluble in benzene and ether.
DOSAGE AND ADMINISTRATION
Dosages of barbiturates must be individualized with full knowledge of their particular characteristics and recommended rate of administration. Factors of consideration are the patient's age, weight, and condition. Parenteral routes should be used only when oral administration is impossible or impractical.
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